IMSI: Purpose, Procedure & Results
Intra-Cytoplasmic Morphologically-Selected Sperm Injection (IMSI)
What is IMSI?
IMSI is an advanced form of IVF designed to address male infertility, especially when sperm shape and structure are compromised (Teratozoospermia). This technique involves selecting sperm under extremely high magnification (up to 6600x) to identify those with the best morphology, significantly improving fertilization, embryo development, and pregnancy outcomes.
When Should You Consider IMSI?
IMSI is especially beneficial in the following scenarios:
- Teratozoospermia – When sperm have abnormal shape or structure affecting embryo formation.
- High DNA Fragmentation – Damaged sperm DNA lowers fertilization and embryo quality.
- Repeated ICSI Failures – IMSI may succeed where standard ICSI has not.
- Sperm Retrieval Cases – In azoospermia or other sperm aspiration procedures.
- Recurrent Miscarriages – IMSI may help reduce early pregnancy loss.
How Does IMSI Work?
- Ovarian Stimulation: The female partner receives medication to produce multiple follicles.
- Egg Retrieval: Mature eggs are collected for fertilization.
- Sperm Selection: Using a powerful microscope (6600x magnification), embryologists closely examine sperm and select the healthiest one with no structural defects.
- Fertilization: The selected sperm is injected directly into the egg (like ICSI).
- Embryo Transfer: The resulting embryo is cultured and transferred to the uterus.
Benefits of IMSI
- Higher embryo quality
- Better fertilization and implantation rates
- Reduced chances of miscarriage
- Improved success in patients with previous IVF/ICSI failures
Fast Facts
When It’s Used
For sperm with abnormal shape and poor morphology
Why It’s Needed
When few embryos reach the blastocyst stage
Ideal Candidates
Sperm with high DNA fragmentation levels